Mouse Anti-PLSCR1 Recombinant Antibody (1F9) (CBMAB-A6814-LY)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5 (By similarity).
Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A (PubMed:27206388, PubMed:17567603).
Negatively regulates FcR-mediated phagocytosis in differentiated macrophages (PubMed:26745724).
May contribute to cytokine-regulated cell proliferation and differentiation (By similarity).
May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes (PubMed:15308695).
Acts as an attachment receptor for HCV (PubMed:21806988).
Apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Defense response to virusManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of phagocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of viral genome replicationManual Assertion Based On ExperimentIMP:UniProtKB
Phosphatidylserine biosynthetic processISS:UniProtKB
Phosphatidylserine exposure on apoptotic cell surfaceManual Assertion Based On ExperimentIMP:UniProtKB
Plasma membrane phospholipid scramblingManual Assertion Based On ExperimentIDA:UniProtKB
Platelet activation1 PublicationNAS:UniProtKB
Positive regulation of chromosome separationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of innate immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of Fc receptor mediated stimulatory signaling pathwayISS:UniProtKB
Regulation of mast cell activationISS:UniProtKB
Response to interferon-betaManual Assertion Based On ExperimentIMP:UniProtKB
Response to lead ionManual Assertion Based On ExperimentIDA:UniProtKB
Nucleus
Cytoplasm
Cytoplasm, perinuclear region
Localizes to the perinuclear region in the presence of RELT (PubMed:22052202).
Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus (PubMed:12564925).
Helical: 289-305
Extracellular: 306-318
Phosphorylated by OXSR1 in the presence of RELT
Palmitoylation is required for its phospholipid scramblase activity (PubMed:9572851).
Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus (PubMed:12564925).
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
Antibody Pairs
PLSCR1 Matched Antibody Pair (892) (CAT#: APMAB-892LY)
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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