Sign in or Register   Sign in or Register
  |  

Rat Anti-PLVAP Recombinant Antibody (CBFYM-3061) (CBMAB-M3257-FY)

This product is rat antibody that recognizes PLVAP. The antibody CBFYM-3061 can be used for immunoassay techniques such as: WB.
See all PLVAP antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBFYM-3061
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
The MECA-32 antibody is specific for mouse BECs but not LECs
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PLVAP
Introduction
Plasmalemmal vesicle‐associated protein is believed to be a component of diaphragmed endothelial fenestrations, but a direct relationship with VEGF signalling has not been established.
Entrez Gene ID
84094
UniProt ID
G3X924
Alternative Names
Pv1; MECA32
Function
Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development.
Biological Process
Developmental processISS:UniProtKB
MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cellular extravasationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of vascular permeabilityManual Assertion Based On ExperimentIBA:GO_Central
Tumor necrosis factor-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Membrane, caveola
Cytoplasm, perinuclear region
Membrane-associated protein of caveolae. Found in fenestral and stomatal diaphragms in fenestrated endothelia and transendothelial channels. Also colocalized with CAV1 in perinuclear region.
Involvement in disease
Diarrhea 10, protein-losing enteropathy type (DIAR10):
An autosomal recessive, congenital diarrheal disorder characterized by intractable secretory diarrhea with massive protein loss due to leaky fenestrated capillaries, severe hypoalbuminemia, hypogammaglobulinemia, hypertriglyceridemia, and electrolyte abnormalities. Disease severity is variable and death in infancy may occur in severe cases. Some patients show facial dysmorphic features, and cardiac and renal abnormalities.
Topology
Cytoplasmic: 1-27
Helical: 28-48
Extracellular: 49-442
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rat Anti-PLVAP Recombinant Antibody (CBFYM-3061)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare