Sign in or Register   Sign in or Register
  |  

Rat Anti-PLVAP Antibody (MECA-32) (CBMAB-1492CQ)

This product is a rat antibody that recognizes PLVAP. The antibody MECA-32 can be used for immunoassay techniques such as: IHC-P, IF, IHC, IP, WB.
See all PLVAP antibodies
Published Data
Fig.1 Intratumoral nintedanib in tissue cryosections detected by confocal fluorescence microscopy using the FITC channel. The endothelial marker MECA-32 was stained to visualize tumor microvasculature.
...View More
Fig.2 A representative contour plot of IgM and IgD expression on peritoneal B cells from wild type, heterozygous or Plvap−/− mice is shown. The number in each corner represents the percentage of IgD+/IgMlo (upper corner) and IgD−/IgM+ (lower corner) B cells.
...View More
Fig.3 Confocal micrographs of spleen frozen sections labeled with anti-Plvap (red), anti-B220 (blue) and CD169 (green).
...View More
Fig.4 Western immunoblotting for MECA-32 and p115 (protein-loading control) in lysates from P21 Lama2−/− and WT cerebral cortices.
...View More

Summary

Host Animal
Rat
Specificity
Mouse, Human
Clone
MECA-32
Antibody Isotype
IgG2a
Application
IHC-P, IF, IHC, IP, WB

Basic Information

Immunogen
Lymph node stroma
Specificity
Mouse, Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PLVAP
Introduction
PLVAP (Plasmalemma Vesicle Associated Protein) involved in the formation of stomatal and fenestral diaphragms of caveolae. May function in microvascular permeability. Diseases associated with PLVAP include Breast Benign Neoplasm and Thoracic Benign Neoplasm.
Entrez Gene ID
Human83483
Mouse84094
UniProt ID
HumanQ9BX97
MouseQ91VC4
Alternative Names
Pv1
Function
Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development.
Biological Process
Developmental processISS:UniProtKB
MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cellular extravasationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of vascular permeabilityManual Assertion Based On ExperimentIBA:GO_Central
Tumor necrosis factor-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Membrane, caveola
Cytoplasm, perinuclear region
Membrane-associated protein of caveolae. Found in fenestral and stomatal diaphragms in fenestrated endothelia and transendothelial channels. Also colocalized with CAV1 in perinuclear region.
Involvement in disease
Diarrhea 10, protein-losing enteropathy type (DIAR10):
An autosomal recessive, congenital diarrheal disorder characterized by intractable secretory diarrhea with massive protein loss due to leaky fenestrated capillaries, severe hypoalbuminemia, hypogammaglobulinemia, hypertriglyceridemia, and electrolyte abnormalities. Disease severity is variable and death in infancy may occur in severe cases. Some patients show facial dysmorphic features, and cardiac and renal abnormalities.
Topology
Cytoplasmic: 1-27
Helical: 28-48
Extracellular: 49-442
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rat Anti-PLVAP Antibody (MECA-32)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare