Rat Anti-PLXNA1 Recombinant Antibody (CBYC-P458) (CBMAB-P2192-YC)

Name: Rat Anti-PLXNA1 Recombinant Antibody (CBYC-P458)
SKU: CBMAB-P2192-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rat

Clone

CBYC-P458

Application

Immunogen

E. coli-derived recombinant mouse Plexin A1, Leu49-Gly165

Specificity

Mouse

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Saline solution containing BSA and sodium azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Plexin A1

Introduction

PLXNA1 (Plexin A1) is a protein coding gene. Diseases associated with PLXNA1 include Hereditary Congenital Facial Paresis and Dubowitz Syndrome. Among its related pathways are Developmental Biology and Semaphorin interactions. Gene Ontology annotations related to this gene include semaphorin receptor activity. An important paralog of the gene is PLXNA3.

Entrez Gene ID

18844

UniProt ID

P70206

Alternative Names

NOV; PLEXIN-A1; PLXN1; NOVP

Function

Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).

Biological Process

Dichotomous subdivision of terminal units involved in salivary gland branchingIEA:Ensembl
Gonadotrophin-releasing hormone neuronal migration to the hypothalamusIEA:Ensembl
Negative regulation of cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Neuron projection extensionIEA:Ensembl
Olfactory nerve formationIEA:Ensembl
Positive regulation of axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Regulation of smooth muscle cell migrationIEA:Ensembl
Semaphorin-plexin signaling pathway involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 27-1244
Helical: 1245-1265
Cytoplasmic: 1245-1265

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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