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Rat Anti-PLXNA1 Recombinant Antibody (CBYC-P458) (CBMAB-P2192-YC)

Provided herein is a Rat monoclonal antibody against Mouse Plexin A1. The antibody can be used for immunoassay techniques, such as FC.
See all PLXNA1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYC-P458
Antibody Isotype
IgG2a
Application
FC

Basic Information

Immunogen
E. coli-derived recombinant mouse Plexin A1, Leu49-Gly165
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Saline solution containing BSA and sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Plexin A1
Introduction
PLXNA1 (Plexin A1) is a protein coding gene. Diseases associated with PLXNA1 include Hereditary Congenital Facial Paresis and Dubowitz Syndrome. Among its related pathways are Developmental Biology and Semaphorin interactions. Gene Ontology annotations related to this gene include semaphorin receptor activity. An important paralog of the gene is PLXNA3.
Entrez Gene ID
18844
UniProt ID
P70206
Alternative Names
NOV; PLEXIN-A1; PLXN1; NOVP
Function
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).
Biological Process
Dichotomous subdivision of terminal units involved in salivary gland branchingIEA:Ensembl
Gonadotrophin-releasing hormone neuronal migration to the hypothalamusIEA:Ensembl
Negative regulation of cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Neuron projection extensionIEA:Ensembl
Olfactory nerve formationIEA:Ensembl
Positive regulation of axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Regulation of smooth muscle cell migrationIEA:Ensembl
Semaphorin-plexin signaling pathway involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 27-1244
Helical: 1245-1265
Cytoplasmic: 1245-1265
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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