PLXNA1

PLXNA1 (Plexin A1) is a protein coding gene. Diseases associated with PLXNA1 include Hereditary Congenital Facial Paresis and Dubowitz Syndrome. Among its related pathways are Developmental Biology and Semaphorin interactions. Gene Ontology annotations related to this gene include semaphorin receptor activity. An important paralog of the gene is PLXNA3.
Full Name
Plexin A1
Function
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).
Biological Process
Dichotomous subdivision of terminal units involved in salivary gland branchingIEA:Ensembl
Gonadotrophin-releasing hormone neuronal migration to the hypothalamusIEA:Ensembl
Negative regulation of cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Neuron projection extensionIEA:Ensembl
Olfactory nerve formationIEA:Ensembl
Positive regulation of axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Regulation of smooth muscle cell migrationIEA:Ensembl
Semaphorin-plexin signaling pathway involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 27-1244
Helical: 1245-1265
Cytoplasmic: 1245-1265
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Anti-PLXNA1 antibodies

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Mouse Anti-PLXNA1 Recombinant Antibody (CBT3668) (V2LY-0625-LY850)

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Target: PLXNA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3668
Application*: IC, F
Datasheet SDS

Mouse Anti-PLXNA1 Recombinant Antibody (CBT3417) (V2LY-0625-LY849)

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Target: PLXNA1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT3417
Application*: F
Datasheet SDS

Mouse Anti-PLXNA1 Recombinant Antibody (CBYC-P459) (CBMAB-P2193-YC)

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Target: PLXNA1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYC-P459
Application*: F
Datasheet SDS

Rat Anti-PLXNA1 Recombinant Antibody (CBYC-P458) (CBMAB-P2192-YC)

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Target: PLXNA1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYC-P458
Application*: F
Datasheet SDS

Mouse Anti-PLXNA1 Recombinant Antibody (11n153) (CBMAB-P2191-YC)

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Target: PLXNA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11n153
Application*: IC, WB
Datasheet SDS

Rabbit Anti-PLXNA1 Recombinant Antibody (BA0241) (CBMAB-0661CQ)

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Target: PLXNA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: BA0241
Application*: F, IC, WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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