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Mouse Anti-PLXNB1 Recombinant Antibody (9L849) (CBMAB-P2204-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
9L849
Antibody Isotype
IgG1
Application
ELISA, FC

Basic Information

Immunogen
Purified, E. coli-derived, Recombinant human Plexin B1 (aa35-150
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 35-150

Target

Full Name
PLXNB1
Introduction
PLXNB1 (Plexin B1) is a protein coding gene. Among its related pathways are Developmental Biology and Signaling by GPCR. Gene Ontology annotations related to this gene include GTPase activating protein binding. An important paralog of the gene is PLXNB3.
Entrez Gene ID
5364
UniProt ID
O43157
Alternative Names
PLEXIN-B1; PLXN5; SEP
Function
Receptor for SEMA4D (PubMed:19843518, PubMed:20877282, PubMed:21912513).
Plays a role in GABAergic synapse development (By similarity).
Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity).
Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12196628, PubMed:15210733).
Plays a role in axon guidance, invasive growth and cell migration (PubMed:12198496).
Biological Process
Cell migration1 PublicationNAS:UniProtKB
Inhibitory synapse assemblyISS:UniProtKB
Intracellular signal transduction1 PublicationNAS:UniProtKB
Negative regulation of cell adhesionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of osteoblast proliferationISS:BHF-UCL
Neuron projection morphogenesisISS:UniProtKB
Ossification involved in bone maturationISS:BHF-UCL
Positive regulation of axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of GTPase activityISS:UniProtKB
Positive regulation of phosphatidylinositol 3-kinase signalingISS:UniProtKB
Regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell shapeManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cytoskeleton organizationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Semaphorin-plexin signaling pathway involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Semaphorin-plexin signaling pathway involved in bone trabecula morphogenesisISS:BHF-UCL
Cellular Location
Isoform 1
Cell membrane
Isoform 2
Secreted
Isoform 3
Secreted
Topology
Extracellular: 20-1490
Helical: 1491-1511
Cytoplasmic: 1512-2135
PTM
Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding.
Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding.
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For research use only. Not intended for any clinical use.

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