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Mouse Anti-PLXNB3 Recombinant Antibody (CBYC-P469) (CBMAB-P2210-YC)

Provided herein is a Mouse monoclonal antibody against Human Plexin B3. The antibody can be used for immunoassay techniques, such as FC.
See all PLXNB3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P469
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Plexin B3
Introduction
PLXNB3 is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration.
Entrez Gene ID
5365
UniProt ID
Q9ULL4
Alternative Names
PLEXB3; PLXN6; PLEXR
Function
Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca2+/Mg2+-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1.
Biological Process
Cell chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Homophilic cell adhesion via plasma membrane adhesion moleculesManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Negative regulation of cell adhesionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of GTPase activityManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of lamellipodium assemblyISS:UniProtKB
Positive chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of endothelial cell proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of neuron projection developmentManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Semaphorin-plexin signaling pathway involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Colocalizes with RIT2/RIN at the plasma membrane.
Topology
Extracellular: 45-1255
Helical: 1256-1276
Cytoplasmic: 1277-1909
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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