PLXNB3

PLXNB3 is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration.

Full Name

Plexin B3

Function

Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca2+/Mg2+-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1.

Biological Process

Cell chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Homophilic cell adhesion via plasma membrane adhesion moleculesManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Negative regulation of cell adhesionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of GTPase activityManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of lamellipodium assemblyISS:UniProtKB
Positive chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of endothelial cell proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of neuron projection developmentManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Semaphorin-plexin signaling pathway involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane
Colocalizes with RIT2/RIN at the plasma membrane.

Topology

Extracellular: 45-1255
Helical: 1256-1276
Cytoplasmic: 1277-1909