Mouse Anti-PNOC Recombinant Antibody (4F6) (CBMAB-P2272-YC)

Name: Mouse Anti-PNOC Recombinant Antibody (4F6)
SKU: CBMAB-P2272-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

4F6

Application

ELISA, WB

Immunogen

PNOC (NP_006219.1, 96-168 aa) partial recombinant protein with GST tag. Immunogen sequence: RRMPRVRSLF QEQEEPEPGM EEAGEMEQKQ LQKRFGGFTG ARKSARKLAN QKRFSEFMRQ YLVLSMQSSQ RRR

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

prepronociceptin

Introduction

PNOC (Prepronociceptin) is a protein coding gene. Diseases associated with PNOC include Pain Agnosia and Agnosia. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology annotations related to this gene include neuropeptide hormone activity and opioid peptide activity.

Entrez Gene ID

5368

UniProt ID

Q13519

Alternative Names

PPNOC; OFQ; ppN/OFQ; NOP; N/OFQ

Function

Nociceptin
Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.
Nocistatin
Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia.
Orphanin FQ2
Has potent analgesic activity.

Biological Process

Chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Female pregnancyIEA:Ensembl
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Sensory perceptionManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Secreted

PTM

Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.
The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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