PNOC

PNOC (Prepronociceptin) is a protein coding gene. Diseases associated with PNOC include Pain Agnosia and Agnosia. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology annotations related to this gene include neuropeptide hormone activity and opioid peptide activity.

Full Name

prepronociceptin

Function

Nociceptin
Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.
Nocistatin
Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia.
Orphanin FQ2
Has potent analgesic activity.

Biological Process

Chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Female pregnancyIEA:Ensembl
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Sensory perceptionManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Secreted

PTM

Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.
The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.