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Mouse Anti-POFUT2 Recombinant Antibody (1A6) (CBMAB-P2291-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein O-Fucosyltransferase 2. The antibody can be used for immunoassay techniques, such as FC, WB.
See all POFUT2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A6
Antibody Isotype
IgG2a
Application
FC, WB

Basic Information

Immunogen
Full length human recombinant protien of human POFUT2(NP_598368) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein O-Fucosyltransferase 2
Introduction
POFUT2 (Protein O-Fucosyltransferase 2) is a protein coding gene. Diseases associated with POFUT2 include Peters-Plus Syndrome. Among its related pathways are O-linked glycosylation and Metabolism of proteins. Gene Ontology annotations related to this gene include fucosyltransferase activity and peptide-O-fucosyltransferase activity.
Entrez Gene ID
23275
UniProt ID
Q9Y2G5
Alternative Names
FUT13; C21orf80
Function
Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively (PubMed:22588082).
O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families (Probable) (PubMed:17395588).
Required for the proper secretion of ADAMTS family members such as ADAMTSL1 and ADAMTS13 (PubMed:17395589, PubMed:17395588).
The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (By similarity).
Biological Process
Fucose metabolic processIEA:UniProtKB-KW
Mesoderm formationIEA:Ensembl
Positive regulation of protein foldingManual Assertion Based On ExperimentIMP:CACAO
Protein O-linked fucosylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of epithelial to mesenchymal transitionIEA:Ensembl
Regulation of gene expressionIEA:Ensembl
Regulation of secretionManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Endoplasmic reticulum
Golgi apparatus
Mainly located in the endoplasmic reticulum.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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