Mouse Anti-POFUT2 Recombinant Antibody (5H1) (CBMAB-P2293-YC)

Name: Mouse Anti-POFUT2 Recombinant Antibody (5H1)
SKU: CBMAB-P2293-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

5H1

Application

FC, WB

Immunogen

Full length human recombinant protein of human POFUT2(NP_598368) produced in HEK293T cell

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Protein O-Fucosyltransferase 2

Introduction

POFUT2 (Protein O-Fucosyltransferase 2) is a protein coding gene. Diseases associated with POFUT2 include Peters-Plus Syndrome. Among its related pathways are O-linked glycosylation and Metabolism of proteins. Gene Ontology annotations related to this gene include fucosyltransferase activity and peptide-O-fucosyltransferase activity.

Entrez Gene ID

23275

UniProt ID

Q9Y2G5

Alternative Names

FUT13; C21orf80

Function

Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively (PubMed:22588082).
O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families (Probable) (PubMed:17395588).
Required for the proper secretion of ADAMTS family members such as ADAMTSL1 and ADAMTS13 (PubMed:17395589, PubMed:17395588).
The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (By similarity).

Biological Process

Fucose metabolic processIEA:UniProtKB-KW
Mesoderm formationIEA:Ensembl
Positive regulation of protein foldingManual Assertion Based On ExperimentIMP:CACAO
Protein O-linked fucosylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of epithelial to mesenchymal transitionIEA:Ensembl
Regulation of gene expressionIEA:Ensembl
Regulation of secretionManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Endoplasmic reticulum
Golgi apparatus
Mainly located in the endoplasmic reticulum.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-POFUT2 Recombinant Antibody (1A6) (CAT#: CBMAB-P2291-YC)

Isotype control

For research use only. Not intended for any clinical use.

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