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Mouse Anti-POGZ Antibody (1B2) (CBMAB-0823-YC)

Provided herein are mouse monoclonal antibodies against Human POGZ. The antibody clone 1B2 can be used for immunoassay techniques, such as ELISA and IP.
See all POGZ antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B2
Antibody Isotype
IgG2b
Application
ELISA, IP

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
POGZ
Introduction
POGZ (pogo transposable element with ZNF domain) appears to be a zinc finger protein containing a transposase domain at the C-terminus. POGZ interacts with the transcription factor SP1 in a yeast two-hybrid system.
Entrez Gene ID
23126
UniProt ID
Q7Z3K3
Alternative Names
MRD37; WHSUS; ZNF635; ZNF280E; ZNF635m
Function
Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864).
Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387).
Biological Process
Cell divisionIEA:UniProtKB-KW
DNA recombinationIEA:UniProtKB-KW
DNA repairIEA:UniProtKB-KW
Kinetochore assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic sister chromatid cohesionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Chromosome
Cytoplasm
According to some authors, it is not localized to mitotic chromatin (PubMed:19244240).
Recruited to trimethylated 'Lys-9' of histone H3 (H3K9me3)
Involvement in disease
White-Sutton syndrome (WHSUS):
An autosomal dominant syndrome characterized by developmental delay, intellectual disability, hypotonia, behavioral abnormalities, and dysmorphic facial features. Variable features include short stature, microcephaly, strabismus and hearing loss.
PTM
Phosphorylation increases its interaction with PSIP1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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