Mouse Anti-POGZ Antibody (1B2) (CBMAB-0823-YC)

Name: Mouse Anti-POGZ Antibody (1B2)
SKU: CBMAB-0823-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

1B2

Application

ELISA, IP

Immunogen

Recombinant protein

Specificity

Human

Antibody Isotype

IgG2b

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

POGZ

Introduction

POGZ (pogo transposable element with ZNF domain) appears to be a zinc finger protein containing a transposase domain at the C-terminus. POGZ interacts with the transcription factor SP1 in a yeast two-hybrid system.

Entrez Gene ID

23126

UniProt ID

Q7Z3K3

Alternative Names

MRD37; WHSUS; ZNF635; ZNF280E; ZNF635m

Function

Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864).
Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387).

Biological Process

Cell divisionIEA:UniProtKB-KW
DNA recombinationIEA:UniProtKB-KW
DNA repairIEA:UniProtKB-KW
Kinetochore assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic sister chromatid cohesionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus
Chromosome
Cytoplasm
According to some authors, it is not localized to mitotic chromatin (PubMed:19244240).
Recruited to trimethylated 'Lys-9' of histone H3 (H3K9me3)

Involvement in disease

White-Sutton syndrome (WHSUS):
An autosomal dominant syndrome characterized by developmental delay, intellectual disability, hypotonia, behavioral abnormalities, and dysmorphic facial features. Variable features include short stature, microcephaly, strabismus and hearing loss.

PTM

Phosphorylation increases its interaction with PSIP1.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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