POGZ

POGZ appears to be a zinc finger protein containing a transposase domain at the C-terminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system.

Full Name

POGZ

Function

Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864).
Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387).

Biological Process

Cell divisionIEA:UniProtKB-KW
DNA recombinationIEA:UniProtKB-KW
DNA repairIEA:UniProtKB-KW
Kinetochore assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic sister chromatid cohesionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus
Chromosome
Cytoplasm
According to some authors, it is not localized to mitotic chromatin (PubMed:19244240).
Recruited to trimethylated 'Lys-9' of histone H3 (H3K9me3)

Involvement in disease

White-Sutton syndrome (WHSUS):
An autosomal dominant syndrome characterized by developmental delay, intellectual disability, hypotonia, behavioral abnormalities, and dysmorphic facial features. Variable features include short stature, microcephaly, strabismus and hearing loss.

PTM

Phosphorylation increases its interaction with PSIP1.