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Mouse Anti-POLN Recombinant Antibody (1G2/2) (CBMAB-P2336-YC)

Provided herein is a Mouse monoclonal antibody against Mouse DNA Polymerase Nu. The antibody can be used for immunoassay techniques, such as WB.
See all POLN antibodies

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
1G2/2
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Recombinant fragment of mouse POLN protein
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DNA Polymerase N
Introduction
POLN is a DNA polymerase type-A family member. The encoded protein plays a role in DNA repair and homologous recombination. This gene shares its 5' exons with some transcripts from overlapping GeneID: 79441, which encodes an augmentin-like protein complex subunit.
Entrez Gene ID
272158
UniProt ID
Q7TQ07
Alternative Names
POL4P
Function
DNA polymerase with very low fidelity that catalyzes considerable misincorporation by inserting dTTP opposite a G template, and dGTP opposite a T template (PubMed:16787914, PubMed:17118716).
Is the least accurate of the DNA polymerase A family (i.e. POLG, POLN and POLQ) (PubMed:17118716).
Can perform accurate translesion DNA synthesis (TLS) past a 5S-thymine glycol. Can perform efficient strand displacement past a nick or a gap and gives rise to an amount of product similar to that on non-damaged template. Has no exonuclease activity (PubMed:16787914).
Error-prone DNA polymerase that preferentially misincorporates dT regardless of template sequence (PubMed:25775266).
May play a role in TLS during interstrand cross-link (ICL) repair (PubMed:19908865).
May be involved in TLS when genomic replication is blocked by extremely large major groove DNA lesions. May function in the bypass of some DNA-protein and DNA-DNA cross-links. May have a role in cellular tolerance to DNA cross-linking agents (PubMed:20102227).
Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with HELQ helicase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links (PubMed:19995904).
Biological Process
DNA-templated DNA replicationIEA:InterPro
Double-strand break repairManual Assertion Based On ExperimentIBA:GO_Central
Double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIMP:UniProtKB
Interstrand cross-link repairManual Assertion Based On ExperimentIMP:UniProtKB
Translesion synthesisManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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