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Mouse Anti-POLR2I Recombinant Antibody (2B3) (CBMAB-P2360-YC)

Provided herein is a Mouse monoclonal antibody against Human RNA Polymerase II Subunit I. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all POLR2I antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2B3
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
POLR2I (AAH17112, AA 26-125 partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
Introduction
POLR2I is a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity.
Entrez Gene ID
5438
UniProt ID
P36954
Alternative Names
hRPB14.5; RPB9
Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity).
Biological Process
Maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoterManual Assertion Based On ExperimentIBA:GO_Central
mRNA cleavageIEA:InterPro
Transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Transcription initiation from RNA polymerase II promoterManual Assertion Based On ExperimentIBA:GO_Central
Transcription-coupled nucleotide-excision repairManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus, nucleolus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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