POLR2I

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity. [provided by RefSeq]

Full Name

polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity).

Biological Process

Maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoterManual Assertion Based On ExperimentIBA:GO_Central
mRNA cleavageIEA:InterPro
Transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Transcription initiation from RNA polymerase II promoterManual Assertion Based On ExperimentIBA:GO_Central
Transcription-coupled nucleotide-excision repairManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus, nucleolus