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Rabbit Anti-POU3F2 Recombinant Antibody (D2C1L) (CBMAB-P2441-YC)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
D2C1L
Antibody Isotype
IgG
Application
WB, IP, IF, ChIP

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
POU3F2
Introduction
POU3F2 is a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells.
Entrez Gene ID
Human5454
Mouse18992
Rat29588
UniProt ID
HumanP20265
MouseP31360
RatP56222
Alternative Names
BRN2; N-Oct3; OCT7; OTF-7; OTF7; POUF3; brn-2; oct-7
Function
Transcription factor that plays a key role in neuronal differentiation (By similarity).
Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity).
Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity).
The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity).
Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity).
Biological Process
Astrocyte developmentIEA:Ensembl
Cellular response to organic substanceIEA:Ensembl
Cerebral cortex radially oriented cell migrationIEA:Ensembl
Epidermis developmentIEA:Ensembl
Forebrain ventricular zone progenitor cell divisionIEA:Ensembl
Hypothalamus cell differentiationIEA:Ensembl
Myelination in peripheral nervous systemIEA:Ensembl
Negative regulation of gene expressionIEA:Ensembl
Nervous system developmentISS:UniProtKB
Neuroendocrine cell differentiationIEA:Ensembl
Neurohypophysis developmentIEA:Ensembl
Neuron developmentISS:UniProtKB
Neuron differentiationISS:UniProtKB
Neuron fate commitmentISS:UniProtKB
Neuron fate specificationISS:UniProtKB
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of multicellular organism growthIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIISS:UniProtKB
Regulation of axonogenesisIEA:Ensembl
Regulation of cell differentiationIEA:Ensembl
Regulation of transcription by RNA polymerase IIISS:UniProtKB
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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