POU3F2

POU3F2 belongs to a large family of transcription factors that bind to the octameric DNA sequence ATGCAAAT. Most of these proteins share a highly homologous region, referred to as the POU domain, that occurs in several mammalian transcription factors, including the octamer-binding proteins Oct1 (POU2F1; MIM 164175) and Oct2 (POU2F2; MIM 164176) and the pituitary protein Pit1 (PIT1; MIM 173110). Class III POU genes are expressed predominantly in the central nervous system (CNS). It is likely that CNS-specific transcription factors such as these play an important role in mammalian neurogenesis by regulating their diverse patterns of gene expression (Schreiber et al., 1993 [PubMed 8441633]; Atanasoski et al., 1995 [PubMed 7601453]).[supplied by OMIM

Full Name

POU3F2

Function

Transcription factor that plays a key role in neuronal differentiation (By similarity).
Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity).
Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity).
The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity).
Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity).

Biological Process

Astrocyte developmentIEA:Ensembl
Cellular response to organic substanceIEA:Ensembl
Cerebral cortex radially oriented cell migrationIEA:Ensembl
Epidermis developmentIEA:Ensembl
Forebrain ventricular zone progenitor cell divisionIEA:Ensembl
Hypothalamus cell differentiationIEA:Ensembl
Myelination in peripheral nervous systemIEA:Ensembl
Negative regulation of gene expressionIEA:Ensembl
Nervous system developmentISS:UniProtKB
Neuroendocrine cell differentiationIEA:Ensembl
Neurohypophysis developmentIEA:Ensembl
Neuron developmentISS:UniProtKB
Neuron differentiationISS:UniProtKB
Neuron fate commitmentISS:UniProtKB
Neuron fate specificationISS:UniProtKB
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of multicellular organism growthIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIISS:UniProtKB
Regulation of axonogenesisIEA:Ensembl
Regulation of cell differentiationIEA:Ensembl
Regulation of transcription by RNA polymerase IIISS:UniProtKB

Cellular Location

Nucleus