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Mouse Anti-POU6F2 Recombinant Antibody (8F9) (CBMAB-P2460-YC)

Provided herein is a Mouse monoclonal antibody against Human POU Class 6 Homeobox 2. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all POU6F2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
8F9
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
POU6F2 (NP_009183, 2-87 aa) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
POU class 6 homeobox 2
Introduction
POU6F2 is a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo-and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition.
Entrez Gene ID
11281
UniProt ID
P78424
Alternative Names
RPF-1; WT5; WTSL
Function
Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA.
Biological Process
Central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Ganglion mother cell fate determinationManual Assertion Based On ExperimentTAS:ProtInc
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentTAS:UniProtKB
Visual perceptionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Involvement in disease
Hereditary susceptibility to Wilms tumor 5 (WT5):
Pediatric malignancy of kidney and one of the most common solid cancers in childhood.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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