POU6F2

POU6F2 is a member of a gene family characterized by the presence of a bipartite DNA-binding domain, consisting of a POU-specific domain and a POU heterodomain, separated by a variable polylinker. POU domain family members are transcriptional regulators, many of which show highly restricted patterns of expression and are known to control cell type-specific differentiation pathways (see review by Phillips and Luisi, 2000 [PubMed 11183772]).[supplied by OMIM

POU class 6 homeobox 2

Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA.

Central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Ganglion mother cell fate determinationManual Assertion Based On ExperimentTAS:ProtInc
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentTAS:UniProtKB
Visual perceptionManual Assertion Based On ExperimentTAS:ProtInc

Nucleus

Hereditary susceptibility to Wilms tumor 5 (WT5):
Pediatric malignancy of kidney and one of the most common solid cancers in childhood.