Mouse Anti-PPARD Antibody (4C2) (CBMAB-0844-YC)

Mouse

Human

4C2

IgG2a

IP, WB, MA

Recombinant protein

Human

IgG2a

Monoclonal

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Supernatant

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Located in aa 72-146

PPARD (peroxisome proliferator-activated receptor delta) is a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARD function as an integrator of transcriptional repression and nuclear receptor signaling. PPARD may play a role in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation.

FAAR; NUC1; NUCI; NR1C2; NUCII; PPARB

Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.

Adipose tissue developmentIEA:Ensembl
Apoptotic processManual Assertion Based On ExperimentIMP:CACAO
Apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Axon ensheathmentISS:UniProtKB
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Cell population proliferationISS:UniProtKB
Cell-substrate adhesionIEA:Ensembl
Cellular response to hypoxiaIEA:Ensembl
Cellular response to lipopolysaccharideIEA:Ensembl
Cholesterol metabolic processManual Assertion Based On ExperimentTAS:UniProtKB
DecidualizationManual Assertion Based On ExperimentTAS:UniProtKB
Embryo implantationManual Assertion Based On ExperimentTAS:UniProtKB
Fat cell proliferationIEA:Ensembl
Fatty acid beta-oxidationISS:UniProtKB
Fatty acid catabolic processManual Assertion Based On ExperimentTAS:UniProtKB
Fatty acid metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Fatty acid transportISS:UniProtKB
Generation of precursor metabolites and energyManual Assertion Based On ExperimentTAS:ProtInc
Glucose metabolic process1 PublicationNAS:UniProtKB
Glucose transmembrane transport1 PublicationNAS:UniProtKB
Heart developmentIEA:Ensembl
Hormone-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Keratinocyte migrationIEA:Ensembl
Keratinocyte proliferationIEA:Ensembl
Lipid metabolic processISS:UniProtKB
Negative regulation of apoptotic processIEA:Ensembl
Negative regulation of cell growthIEA:Ensembl
Negative regulation of cholesterol storageManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of collagen biosynthetic processIEA:Ensembl
Negative regulation of epithelial cell proliferationIEA:Ensembl
Negative regulation of inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of miRNA transcriptionISS:BHF-UCL
Negative regulation of myoblast differentiationIEA:Ensembl
Negative regulation of smooth muscle cell migrationIEA:Ensembl
Negative regulation of smooth muscle cell proliferationIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIISS:UniProtKB
Negative regulation of transcription, DNA-templatedISS:UniProtKB
Phosphatidylinositol 3-kinase signalingIEA:Ensembl
Phospholipid biosynthetic processIEA:Ensembl
Positive regulation of epidermis developmentIEA:Ensembl
Positive regulation of fat cell differentiation1 PublicationNAS:UniProtKB
Positive regulation of fat cell proliferationIEA:Ensembl
Positive regulation of fatty acid metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of fatty acid oxidationIEA:Ensembl
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of insulin secretion involved in cellular response to glucose stimulusIEA:Ensembl
Positive regulation of myoblast proliferationIEA:Ensembl
Positive regulation of phosphatidylinositol 3-kinase signalingIEA:Ensembl
Positive regulation of skeletal muscle tissue regenerationIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Proteoglycan metabolic processIEA:Ensembl
Regulation of lipid metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Regulation of skeletal muscle satellite cell proliferationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Response to activityIEA:Ensembl
Response to glucoseIEA:Ensembl
Response to lipidManual Assertion Based On ExperimentIBA:GO_Central
Response to vitamin AIEA:Ensembl
VasodilationIEA:Ensembl
Vitamin A metabolic processIEA:Ensembl
Wound healingIEA:Ensembl

Nucleus