PPARD

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. [provided by RefSeq]

PPARD

Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.

Adipose tissue developmentIEA:Ensembl
Apoptotic processManual Assertion Based On ExperimentIMP:CACAO
Apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Axon ensheathmentISS:UniProtKB
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Cell population proliferationISS:UniProtKB
Cell-substrate adhesionIEA:Ensembl
Cellular response to hypoxiaIEA:Ensembl
Cellular response to lipopolysaccharideIEA:Ensembl
Cholesterol metabolic processManual Assertion Based On ExperimentTAS:UniProtKB
DecidualizationManual Assertion Based On ExperimentTAS:UniProtKB
Embryo implantationManual Assertion Based On ExperimentTAS:UniProtKB
Fat cell proliferationIEA:Ensembl
Fatty acid beta-oxidationISS:UniProtKB
Fatty acid catabolic processManual Assertion Based On ExperimentTAS:UniProtKB
Fatty acid metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Fatty acid transportISS:UniProtKB
Generation of precursor metabolites and energyManual Assertion Based On ExperimentTAS:ProtInc
Glucose metabolic process1 PublicationNAS:UniProtKB
Glucose transmembrane transport1 PublicationNAS:UniProtKB
Heart developmentIEA:Ensembl
Hormone-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Keratinocyte migrationIEA:Ensembl
Keratinocyte proliferationIEA:Ensembl
Lipid metabolic processISS:UniProtKB
Negative regulation of apoptotic processIEA:Ensembl
Negative regulation of cell growthIEA:Ensembl
Negative regulation of cholesterol storageManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of collagen biosynthetic processIEA:Ensembl
Negative regulation of epithelial cell proliferationIEA:Ensembl
Negative regulation of inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of miRNA transcriptionISS:BHF-UCL
Negative regulation of myoblast differentiationIEA:Ensembl
Negative regulation of smooth muscle cell migrationIEA:Ensembl
Negative regulation of smooth muscle cell proliferationIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIISS:UniProtKB
Negative regulation of transcription, DNA-templatedISS:UniProtKB
Phosphatidylinositol 3-kinase signalingIEA:Ensembl
Phospholipid biosynthetic processIEA:Ensembl
Positive regulation of epidermis developmentIEA:Ensembl
Positive regulation of fat cell differentiation1 PublicationNAS:UniProtKB
Positive regulation of fat cell proliferationIEA:Ensembl
Positive regulation of fatty acid metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of fatty acid oxidationIEA:Ensembl
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of insulin secretion involved in cellular response to glucose stimulusIEA:Ensembl
Positive regulation of myoblast proliferationIEA:Ensembl
Positive regulation of phosphatidylinositol 3-kinase signalingIEA:Ensembl
Positive regulation of skeletal muscle tissue regenerationIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Proteoglycan metabolic processIEA:Ensembl
Regulation of lipid metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Regulation of skeletal muscle satellite cell proliferationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Response to activityIEA:Ensembl
Response to glucoseIEA:Ensembl
Response to lipidManual Assertion Based On ExperimentIBA:GO_Central
Response to vitamin AIEA:Ensembl
VasodilationIEA:Ensembl
Vitamin A metabolic processIEA:Ensembl
Wound healingIEA:Ensembl

Nucleus