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Mouse Anti-PPIL2 Recombinant Antibody (2E11) (CBMAB-P2539-YC)

Provided herein is a Mouse monoclonal antibody against Human Peptidylprolyl Isomerase Like 2. The antibody can be used for immunoassay techniques, such as ELISA.
See all PPIL2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2E11
Antibody Isotype
IgG2b, κ
Application
ELISA

Basic Information

Immunogen
PPIL2 (AAH00022, 1-528 aa) full length recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
peptidylprolyl isomerase (cyclophilin)-like 2
Introduction
PPIL2 (Peptidylprolyl Isomerase Like 2) is a protein coding gene. Among its related pathways are Basigin interactions and Ubiquitin mediated proteolysis. Gene Ontology annotations related to this gene include ligase activity and ubiquitin protein ligase activity.
Entrez Gene ID
23759
UniProt ID
Q13356
Alternative Names
CYC4; CYP60; Cyp-60; UBOX7; hCyP-60
Function
Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423).
May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance (PubMed:15946952).
Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357).
Biological Process
Protein foldingIEA:InterPro
Protein localization to plasma membraneManual Assertion Based On ExperimentIMP:UniProtKB
Protein peptidyl-prolyl isomerizationIEA:InterPro
Protein polyubiquitinationManual Assertion Based On ExperimentIDA:MGI
Cellular Location
Nucleus
May also localize to the cytoplasm and the cell membrane.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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