PPIL2

This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Full Name

peptidylprolyl isomerase (cyclophilin)-like 2

Function

Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423).
May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance (PubMed:15946952).
Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357).

Biological Process

Protein foldingIEA:InterPro
Protein localization to plasma membraneManual Assertion Based On ExperimentIMP:UniProtKB
Protein peptidyl-prolyl isomerizationIEA:InterPro
Protein polyubiquitinationManual Assertion Based On ExperimentIDA:MGI

Cellular Location

Nucleus
May also localize to the cytoplasm and the cell membrane.