loading...

PPIL2

This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Full Name

peptidylprolyl isomerase (cyclophilin)-like 2

Function

Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423).
May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance (PubMed:15946952).
Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357).

Biological Process

Protein foldingIEA:InterPro
Protein localization to plasma membraneManual Assertion Based On ExperimentIMP:UniProtKB
Protein peptidyl-prolyl isomerizationIEA:InterPro
Protein polyubiquitinationManual Assertion Based On ExperimentIDA:MGI

Cellular Location

Nucleus
May also localize to the cytoplasm and the cell membrane.

View more

Anti-PPIL2 antibodies

+ Filters

Loading...

Mouse Anti-PPIL2 Recombinant Antibody (2A10) (CBMAB-A6945-LY)

Compare

Target: PPIL2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 2A10

Application*: SE, E

Mouse Anti-PPIL2 Recombinant Antibody (A-9) (CBMAB-P2540-YC)

Compare

Target: PPIL2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: A-9

Application*: WB, IP, IF, E

Mouse Anti-PPIL2 Recombinant Antibody (2E11) (CBMAB-P2539-YC)

Compare

Target: PPIL2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 2E11

Application*: E

Human Recombinant PPIL2 protein, His Tag (V2LY-0526-LY6263)

Compare

Target: PPIL2

Expressed Host: E. coli

Sequence: Amino Acid: 280-457

Tag: His Tag

More Infomation

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

online inquiry

Online Inquiry