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Mouse Anti-PPP1R3C Recombinant Antibody (2G9) (CBMAB-P2620-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein Phosphatase 1 Regulatory Subunit 3C. The antibody can be used for immunoassay techniques, such as ELISA.
See all PPP1R3C antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2G9
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
PPP1R3C (AAH12625, 1-317 aa) full length recombinant protein with GST tag. Immunogen sequence: MSCTRMIQVL DPRPLTSSVM PVDVAMRLCL AHSPPVKSFL GPYDEFQRRH FVNKLKPLKS CLNIKHKAKS QNDWKCSHNQ AKKRVVFADS KGLSLTAIHV FSDLPEEPAW DLQFDLLDLN DISSALKHHE EKNLILDFPQ PSTDYLSFRS HFQKNFVCLE NCSLQERTVT GTVKVKNVSF EKKVQIRITF DSWKNYTDVD CVYMKNVYGG TDSDTFSFAI DLPPVIPTEQ KIEFCISYHA NGQVFWDNND GQNYRIVHVQ WKPDGVQTQM APQDCAFHQT SPKTELESTI FGSPRLASGL FPEWQSWGRM ENLASYR
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-317

Target

Full Name
protein phosphatase 1, regulatory (inhibitor) subunit 3C
Introduction
PPP1R3C is a carbohydrate binding protein that is a subunit of the protein phosphatase 1 (PP1) complex. PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities. The encoded protein affects glycogen biosynthesis by activating glycogen synthase and limiting glycogen breakdown by reducing glycogen phosphorylase activity. DNA hypermethylation of this gene has been found in colorectal cancer patients.
Entrez Gene ID
5507
UniProt ID
Q9UQK1
Alternative Names
PPP1R5
Function
Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types.
Biological Process
Glycogen biosynthetic processISS:UniProtKB
Glycogen metabolic processISS:UniProtKB
Regulation of glycogen biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
cytosol
protein phosphatase type 1 complex
PTM
Ubiquitinated by NHLRC1/malin in a EPM2A/laforin-dependent manner.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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