PPP1R3C

Protein phosphatase-1 (PP1; see MIM 176875) participates in the regulation of a wide variety of cellular functions by reversible protein phosphorylation. The ability of PP1 to regulate diverse functions resides in its capacity to interact with a variety of regulatory subunits that may target PP1 to specific subcellular locations, modulate its substrate specificity, and allow its activity to be responsive to extracellular signals. Several targeting subunits of PP1 have been identified, including PPP1R5, the glycogen-binding subunits PPP1R3 (MIM 600917) and PPP1R4, and the nuclear inhibitor of PP1 (PPP1R8; MIM 602636).[supplied by OMIM

protein phosphatase 1, regulatory (inhibitor) subunit 3C

Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types.

Glycogen biosynthetic processISS:UniProtKB
Glycogen metabolic processISS:UniProtKB
Regulation of glycogen biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central

cytosol
protein phosphatase type 1 complex

Ubiquitinated by NHLRC1/malin in a EPM2A/laforin-dependent manner.