Mouse Anti-PPP1R8 Recombinant Antibody (4B5) (CBMAB-N4116-WJ)

Name: Mouse Anti-PPP1R8 Recombinant Antibody (4B5)
SKU: CBMAB-N4116-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4B5

Application

ELISA, IP, WB

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

protein phosphatase 1, regulatory (inhibitor) subunit 8

Introduction

PPP1R8 (Protein Phosphatase 1 Regulatory Subunit 8) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is SLC4A1AP.

Entrez Gene ID

5511

UniProt ID

Q12972

Alternative Names

ARD1; ARD-1; NIPP1; NIPP-1; PRO2047

Function

Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.
Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.

Biological Process

Cell population proliferationIEA:Ensembl
mRNA processingIEA:UniProtKB-KW
Negative regulation of protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
RNA catabolic processManual Assertion Based On ExperimentTAS:ProtInc
RNA splicingIEA:UniProtKB-KW

Cellular Location

Nucleus
Nucleus speckle
Primarily, but not exclusively, nuclear.
Isoform Gamma
Cytoplasm
Found mainly in the cytoplasm.

PTM

May be inactivated by phosphorylation on Ser-199 or Ser-204 (By similarity).
Phosphorylated by Lyn in vitro on Tyr-264, and also on Tyr-335 in the presence of RNA.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-PPP1R8 Recombinant Antibody (4E5) (CAT#: CBMAB-N4115-WJ)

Isotype control

For research use only. Not intended for any clinical use.

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