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Mouse Anti-PPP1R8 Recombinant Antibody (4E5) (CBMAB-N4115-WJ)

This product is a Mouse antibody that recognizes PPP1R8. The antibody 4E5 can be used for immunoassay techniques such as: WB, IHC.
See all PPP1R8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4E5
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein phosphatase 1, regulatory (inhibitor) subunit 8
Introduction
PPP1R8 (Protein Phosphatase 1 Regulatory Subunit 8) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is SLC4A1AP.
Entrez Gene ID
5511
UniProt ID
Q12972
Alternative Names
ARD1; ARD-1; NIPP1; NIPP-1; PRO2047
Function
Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.
Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.
Biological Process
Cell population proliferationIEA:Ensembl
mRNA processingIEA:UniProtKB-KW
Negative regulation of protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
RNA catabolic processManual Assertion Based On ExperimentTAS:ProtInc
RNA splicingIEA:UniProtKB-KW
Cellular Location
Nucleus
Nucleus speckle
Primarily, but not exclusively, nuclear.
Isoform Gamma
Cytoplasm
Found mainly in the cytoplasm.
PTM
May be inactivated by phosphorylation on Ser-199 or Ser-204 (By similarity).
Phosphorylated by Lyn in vitro on Tyr-264, and also on Tyr-335 in the presence of RNA.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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