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Mouse Anti-PPP2R1A Recombinant Antibody (4E6) (CBMAB-P2629-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein Phosphatase 2 Scaffold Subunit Aalpha. The antibody can be used for immunoassay techniques, such as ELISA, PLA, WB.
See all PPP2R1A antibodies
Published Data
Fig.1 Regulation of PPP2R1A expression.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
4E6
Antibody Isotype
IgG1, κ
Application
ELISA, PLA, WB

Basic Information

Immunogen
PPP2R1A (AAH01537, 1-589 aa) full length recombinant protein with GST tag. Immunogen sequence: MAAADGDDSL YPIAVLIDEL RNEDVQLRLN SIKKLSTIAL ALGVERTRSE LLPFLTDTIY DEDEVLLALA EQLGTFATLV GGPEYVHCLL PPLESLATVE ETVVRDKAVE SLRAISHEHS PSDLEAHFVP LVKRLAGGDW FTSRTSACGL FSVCYPRVSS AVKAELRQYF RNLCSDDTPM VRRAAASKLG EFAKVLELDN VKSEIIPMFS NLASDEQDSV RLLAVEACVN IAQLLPQEDL EALVMPTLRQ AAEDKSWRVR YMVADKFTEL QKAVGPEITK TDLVPAFQNL MKDCEAEVRA AASHKVKEFC ENLSADCREN VIMSQILPCI KELVSDANQH VKSALASVIM GLSPILGKDN TIEHLLPLFL AQLKDECPEV RLNIISNLDC VNEVIGIRQL SQSLLPAIVE LAEDAKWRVR LAIIEYMPLL AGQLGVEFFD EKLNSLCMAW LVDHVYAIRE AATSNLKKLV EKFGKEWAHA TIIPKVLAMS GDPNYLHRMT TLFCINVLSE VCGQDITTKH MLPTVLRMAG DPVANVRFNV AKSLQKIGPI LDNSTLQSEV KPILEKLTQD QDVDVKYFAQ EALTVLSLA
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-589

Target

Full Name
protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform
Introduction
PPP2R1A is a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.
Entrez Gene ID
5518
UniProt ID
P30153
Alternative Names
MRD36; PP2A-Aalpha; PP2AA; PP2AAALPHA; PR65A
Function
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (PubMed:15525651).
Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (PubMed:16580887).
Biological Process
Apoptotic processManual Assertion Based On ExperimentTAS:UniProtKB
Ceramide metabolic process1 PublicationNAS:UniProtKB
Chromosome segregationManual Assertion Based On ExperimentIDA:UniProtKB
Female meiotic nuclear divisionIEA:Ensembl
Meiotic sister chromatid cohesion, centromericIEA:Ensembl
Meiotic spindle elongationIEA:Ensembl
Mitotic sister chromatid separationIEA:Ensembl
Negative regulation of cell growth1 PublicationNAS:UniProtKB
Negative regulation of MAPK cascade1 PublicationNAS:UniProtKB
Negative regulation of tyrosine phosphorylation of STAT protein1 PublicationNAS:UniProtKB
Peptidyl-serine dephosphorylationIEA:Ensembl
Positive regulation of extrinsic apoptotic signaling pathway in absence of ligandIEA:Ensembl
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Protein-containing complex assemblyManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of cell adhesion1 PublicationNAS:UniProtKB
Regulation of cell differentiation1 PublicationNAS:UniProtKB
Regulation of DNA replication1 PublicationNAS:UniProtKB
Regulation of growth1 PublicationNAS:UniProtKB
Regulation of meiotic cell cycle process involved in oocyte maturationIEA:Ensembl
Regulation of transcription, DNA-templated1 PublicationNAS:UniProtKB
Regulation of Wnt signaling pathway1 PublicationNAS:UniProtKB
Response to organic substance1 PublicationNAS:UniProtKB
RNA splicing1 PublicationNAS:UniProtKB
Second-messenger-mediated signaling1 PublicationNAS:UniProtKB
Involvement in disease
Intellectual developmental disorder, autosomal dominant 36 (MRD36):
Intellectual developmental disorder, autosomal dominant 36 (MRD36)
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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