PPP2R1A

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. [provided by RefSeq]

Full Name

protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform

Function

The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (PubMed:15525651).
Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (PubMed:16580887).

Biological Process

Apoptotic processManual Assertion Based On ExperimentTAS:UniProtKB
Ceramide metabolic process1 PublicationNAS:UniProtKB
Chromosome segregationManual Assertion Based On ExperimentIDA:UniProtKB
Female meiotic nuclear divisionIEA:Ensembl
Meiotic sister chromatid cohesion, centromericIEA:Ensembl
Meiotic spindle elongationIEA:Ensembl
Mitotic sister chromatid separationIEA:Ensembl
Negative regulation of cell growth1 PublicationNAS:UniProtKB
Negative regulation of MAPK cascade1 PublicationNAS:UniProtKB
Negative regulation of tyrosine phosphorylation of STAT protein1 PublicationNAS:UniProtKB
Peptidyl-serine dephosphorylationIEA:Ensembl
Positive regulation of extrinsic apoptotic signaling pathway in absence of ligandIEA:Ensembl
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Protein-containing complex assemblyManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of cell adhesion1 PublicationNAS:UniProtKB
Regulation of cell differentiation1 PublicationNAS:UniProtKB
Regulation of DNA replication1 PublicationNAS:UniProtKB
Regulation of growth1 PublicationNAS:UniProtKB
Regulation of meiotic cell cycle process involved in oocyte maturationIEA:Ensembl
Regulation of transcription, DNA-templated1 PublicationNAS:UniProtKB
Regulation of Wnt signaling pathway1 PublicationNAS:UniProtKB
Response to organic substance1 PublicationNAS:UniProtKB
RNA splicing1 PublicationNAS:UniProtKB
Second-messenger-mediated signaling1 PublicationNAS:UniProtKB

Involvement in disease

Intellectual developmental disorder, autosomal dominant 36 (MRD36):
Intellectual developmental disorder, autosomal dominant 36 (MRD36)