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Rabbit Anti-PPP2R2A Recombinant Antibody (F.722.1) (CBMAB-P2633-YC)

Provided herein is a Rabbit monoclonal antibody against Human Protein Phosphatase 2 Regulatory Subunit Balpha. The antibody can be used for immunoassay techniques, such as IHC-P, IP, WB.
See all PPP2R2A antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Cattle, Chicken, Friut fly, Mouse, Pig, Rat
Clone
F.722.1
Antibody Isotype
IgG
Application
IHC-P, IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to the sequence of human PP2A B subunit
Specificity
Human, Cattle, Chicken, Friut fly, Mouse, Pig, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
10 mM HEPES with 150 mM sodium chloride, 100 μg/mL BSA, 50% glycerol, 0.02% sodium azide, pH 7.5
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein Phosphatase 2 Regulatory Subunit Balpha
Introduction
PPP2R2A belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity.
Entrez Gene ID
Human5520
Mouse71978
Rat117104
Chicken419523
Cattle508045
Pig397090
UniProt ID
HumanP63151
MouseQ6P1F6
RatP36876
ChickenQ5ZLP4
CattleF1MG56
PigQ29090
Alternative Names
B55ALPHA; B55A; 2410004D02Rik; PR52A; PR55alpha; PR55A; mKIAA1541
Function
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758).
Biological Process
Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Response to morphineIEA:Ensembl
Cellular Location
cytosol
glutamatergic synapse
nucleoplasm
protein phosphatase type 2A complex
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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