PPP2R2A

PPP2R2A belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity.

Full Name

Protein Phosphatase 2 Regulatory Subunit Balpha

Function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758).

Biological Process

Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Response to morphineIEA:Ensembl

Cellular Location

cytosol
glutamatergic synapse
nucleoplasm
protein phosphatase type 2A complex