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Mouse Anti-PPP3R1 Recombinant Antibody (4E1) (CBMAB-P2658-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein Phosphatase 3 Regulatory Subunit B, Alpha. The antibody can be used for immunoassay techniques, such as ELISA, IF, WB.
See all PPP3R1 antibodies
Published Data
Fig.1 Western blot of PPP3R1 in BeWo cells transfected with Pre-miR-512-3p (512-3p) compared with the negative control.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
4E1
Antibody Isotype
IgG1, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
PPP3R1 (AAH27913, AA 1-170 full length recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform
Introduction
PPP3R1 (Protein Phosphatase 3 Regulatory Subunit B, Alpha) is a protein coding gene. Diseases associated with PPP3R1 include Synostoses, Tarsal, Carpal, And Digital andExtracranial Neuroblastoma. Among its related pathways are Antigen activates B Cell Receptor (BCR) leading to generation of second messengers and T cell receptor signaling pathway. Gene Ontology annotations related to this gene include calcium ion binding and calmodulin binding.
Entrez Gene ID
5534
UniProt ID
P63098
Alternative Names
CALNB1; CNB; CNB1
Function
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
Biological Process
Branching involved in blood vessel morphogenesisIEA:Ensembl
Calcineurin-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Calcineurin-NFAT signaling cascadeManual Assertion Based On ExperimentIDA:BHF-UCL
Epithelial to mesenchymal transitionIEA:Ensembl
Heart developmentIEA:Ensembl
Lung epithelial cell differentiationIEA:Ensembl
Myelination in peripheral nervous systemIEA:Ensembl
Negative regulation of calcium ion import across plasma membrane1 PublicationIC:ComplexPortal
Negative regulation of voltage-gated calcium channel activity1 PublicationIC:ComplexPortal
Positive regulation of calcineurin-NFAT signaling cascade2 PublicationsIC:ComplexPortal
Positive regulation of calcium ion import across plasma membrane1 PublicationIC:ComplexPortal
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of voltage-gated calcium channel activity1 PublicationIC:ComplexPortal
Postsynaptic modulation of chemical synaptic transmissionIEA:Ensembl
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Protein import into nucleusIEA:Ensembl
Regulation of postsynaptic neurotransmitter receptor internalizationIEA:Ensembl
Cellular Location
Cytoplasm, cytosol
Cell membrane
Cell membrane, sarcolemma
Cell membrane
Translocates from the cytosol to the sarcolemma in a CIB1-dependent manner during cardiomyocyte hypertrophy.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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