PPP3R1

PPP3R1 (Protein Phosphatase 3 Regulatory Subunit B, Alpha) is a Protein Coding gene. Diseases associated with PPP3R1 include Synostoses, Tarsal, Carpal, And Digital and Extracranial Neuroblastoma. Among its related pathways are Antigen activates B Cell Receptor (BCR) leading to generation of second messengers and T cell receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calmodulin binding. An important paralog of this gene is ENSG00000273398.

Full Name

protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform

Function

Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

Biological Process

Branching involved in blood vessel morphogenesisIEA:Ensembl
Calcineurin-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Calcineurin-NFAT signaling cascadeManual Assertion Based On ExperimentIDA:BHF-UCL
Epithelial to mesenchymal transitionIEA:Ensembl
Heart developmentIEA:Ensembl
Lung epithelial cell differentiationIEA:Ensembl
Myelination in peripheral nervous systemIEA:Ensembl
Negative regulation of calcium ion import across plasma membrane1 PublicationIC:ComplexPortal
Negative regulation of voltage-gated calcium channel activity1 PublicationIC:ComplexPortal
Positive regulation of calcineurin-NFAT signaling cascade2 PublicationsIC:ComplexPortal
Positive regulation of calcium ion import across plasma membrane1 PublicationIC:ComplexPortal
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of voltage-gated calcium channel activity1 PublicationIC:ComplexPortal
Postsynaptic modulation of chemical synaptic transmissionIEA:Ensembl
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Protein import into nucleusIEA:Ensembl
Regulation of postsynaptic neurotransmitter receptor internalizationIEA:Ensembl

Cellular Location

Cytoplasm, cytosol
Cell membrane
Cell membrane, sarcolemma
Cell membrane
Translocates from the cytosol to the sarcolemma in a CIB1-dependent manner during cardiomyocyte hypertrophy.