PPP3R1

PPP3R1 (Protein Phosphatase 3 Regulatory Subunit B, Alpha) is a Protein Coding gene. Diseases associated with PPP3R1 include Synostoses, Tarsal, Carpal, And Digital and Extracranial Neuroblastoma. Among its related pathways are Antigen activates B Cell Receptor (BCR) leading to generation of second messengers and T cell receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calmodulin binding. An important paralog of this gene is ENSG00000273398.

protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform

Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

Branching involved in blood vessel morphogenesisIEA:Ensembl
Calcineurin-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Calcineurin-NFAT signaling cascadeManual Assertion Based On ExperimentIDA:BHF-UCL
Epithelial to mesenchymal transitionIEA:Ensembl
Heart developmentIEA:Ensembl
Lung epithelial cell differentiationIEA:Ensembl
Myelination in peripheral nervous systemIEA:Ensembl
Negative regulation of calcium ion import across plasma membrane1 PublicationIC:ComplexPortal
Negative regulation of voltage-gated calcium channel activity1 PublicationIC:ComplexPortal
Positive regulation of calcineurin-NFAT signaling cascade2 PublicationsIC:ComplexPortal
Positive regulation of calcium ion import across plasma membrane1 PublicationIC:ComplexPortal
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of voltage-gated calcium channel activity1 PublicationIC:ComplexPortal
Postsynaptic modulation of chemical synaptic transmissionIEA:Ensembl
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Protein import into nucleusIEA:Ensembl
Regulation of postsynaptic neurotransmitter receptor internalizationIEA:Ensembl

Cytoplasm, cytosol
Cell membrane
Cell membrane, sarcolemma
Cell membrane
Translocates from the cytosol to the sarcolemma in a CIB1-dependent manner during cardiomyocyte hypertrophy.