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Mouse Anti-PRAG1 Recombinant Antibody (5C6) (CBMAB-P2681-YC)

Provided herein is a Mouse monoclonal antibody against Human PEAK1 related kinase activating pseudokinase 1. The antibody can be used for immunoassay techniques, such as ELISA, IHC, WB.
See all PRAG1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5C6
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid in PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PEAK1 related, kinase-activating pseudokinase 1
Introduction
PRAG1 is an enzyme that belongs to the tyrosine protein kinase family. A similar protein in rat binds to Rho family GTPase 2 (Rnd2) and regulates neurite outgrowth via activation of Ras homolog gene family, member A (RhoA).
Entrez Gene ID
157285
UniProt ID
Q86YV5
Alternative Names
NACK; PEAK2; PRAGMIN; SGK223
Function
Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity).
Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity).
Acts as a critical coactivator of Notch signaling (By similarity).
Biological Process
Cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of neuron projection developmentISS:UniProtKB
Positive regulation of Rho protein signal transductionISS:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell motilityISS:UniProtKB
Regulation of cell shapeISS:UniProtKB
Regulation of Notch signaling pathwayISS:UniProtKB
Cellular Location
Cytoplasm
Cell junction, focal adhesion
Nucleus
Colocalized with NOTCH1 in the nucleus.
PTM
Phosphorylated by CSK on Tyr-253, Tyr-365, and Tyr-413; Tyr-413 is a primary site of phosphorylation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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