Rat Anti-PRCP Recombinant Antibody (CBYJL-2321) (CBMAB-L2620-YJ)

Name: Rat Anti-PRCP Recombinant Antibody (CBYJL-2321)
SKU: CBMAB-L2620-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBYJL-2321

Application

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Lysosomal Pro-X Carboxypeptidase/PRCP, Met1-His496, Accession # P42785.

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, Trehalose

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

prolylcarboxypeptidase (angiotensinase C)

Introduction

PRCP is a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. PRCP cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. PRCP has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Entrez Gene ID

5547

UniProt ID

P42785

Alternative Names

PCP; HUMPCP; lysosomal Pro-X carboxypeptidase; angiotensinase C; lysosomal carboxypeptidase C; proline carboxypeptidase; EC 3.4.16.2

Function

Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.

Biological Process

Angiogenesis involved in wound healingManual Assertion Based On ExperimentIBA:GO_Central
Energy homeostasisIEA:Ensembl
Glucose homeostasisIEA:Ensembl
Negative regulation of systemic arterial blood pressureManual Assertion Based On ExperimentIBA:GO_Central
Plasma kallikrein-kinin cascadeIEA:Ensembl
ProteolysisIEA:UniProtKB-KW
Regulation of blood vessel endothelial cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of reactive oxygen species metabolic processIEA:Ensembl
Regulation of thyroid hormone mediated signaling pathwayIEA:Ensembl

Cellular Location

Lysosome

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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