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Rat Anti-PRCP Recombinant Antibody (CBYJL-2321) (CBMAB-L2620-YJ)

Provided herein is a Rat monoclonal antibody, which binds to Prolylcarboxypeptidase (PRCP). The antibody can be used for immunoassay techniques, such as WB.
See all PRCP antibodies

Summary

Host Animal
Rat
Specificity
Human
Clone
CBYJL-2321
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Lysosomal Pro-X Carboxypeptidase/PRCP, Met1-His496, Accession # P42785.
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, Trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
prolylcarboxypeptidase (angiotensinase C)
Introduction
PRCP is a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. PRCP cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. PRCP has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Entrez Gene ID
UniProt ID
Alternative Names
PCP; HUMPCP; lysosomal Pro-X carboxypeptidase; angiotensinase C; lysosomal carboxypeptidase C; proline carboxypeptidase; EC 3.4.16.2
Function
Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.
Biological Process
Angiogenesis involved in wound healingManual Assertion Based On ExperimentIBA:GO_Central
Energy homeostasisIEA:Ensembl
Glucose homeostasisIEA:Ensembl
Negative regulation of systemic arterial blood pressureManual Assertion Based On ExperimentIBA:GO_Central
Plasma kallikrein-kinin cascadeIEA:Ensembl
ProteolysisIEA:UniProtKB-KW
Regulation of blood vessel endothelial cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of reactive oxygen species metabolic processIEA:Ensembl
Regulation of thyroid hormone mediated signaling pathwayIEA:Ensembl
Cellular Location
Lysosome
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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