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Mouse Anti-PRDM2 Antibody (2A4) (CBMAB-0864-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2A4
Antibody Isotype
IgG1
Application
IP, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
Located in aa 1-148

Target

Full Name
PRDM2
Introduction
PRDM2 (PR domain containing 2, with ZNF domain) is a tumor suppressor belonging to a nuclear histone/protein methyltransferase superfamily. PRDM2 may play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma. Besides, PRDM2 acts as a transcriptional activator of the heme-oxygenase-1 gene and be a specific effector of estrogen action.
Entrez Gene ID
7799
UniProt ID
Q13029
Alternative Names
HUMHOXY1; KMT8; MTB-ZF; RIZ; RIZ1; RIZ2
Function
S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.
Biological Process
Determination of adult lifespanIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templated2 PublicationsNAS:UniProtKB
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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