PRDM2

PRDM2 is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action.
Full Name
PRDM2
Function
S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.
Biological Process
Determination of adult lifespanIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templated2 PublicationsNAS:UniProtKB
Cellular Location
Nucleus
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Anti-PRDM2 antibodies

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Mouse Anti-PRDM2 Recombinant Antibody (RIZ1723) (CBMAB-R0655-CN)

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Target: PRDM2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: RIZ1723
Application*: ICC, IP
Datasheet SDS

Mouse Anti-PRDM2 Recombinant Antibody (33AT1045) (CBMAB-R0654-CN)

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Target: PRDM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human
Clone: 33AT1045
Application*: WB, E
Datasheet SDS

Mouse Anti-PRDM2 Antibody (2A4) (CBMAB-0864-YC)

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Target: PRDM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2A4
Application*: IP, M
Datasheet SDS

Mouse Anti-PRDM2 Antibody (2A1) (CBMAB-0863-YC)

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Target: PRDM2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2A1
Application*: IP, WB, M
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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