Sign in or Register   Sign in or Register
  |  

Mouse Anti-PRKAB2 Recombinant Antibody (2G9) (CBMAB-P2791-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2. The antibody can be used for immunoassay techniques, such as WB.
See all PRKAB2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2G9
Antibody Isotype
IgG2b, κ
Application
WB

Basic Information

Immunogen
PRKAB2 (AAH53610, 1-273 aa) full length recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein kinase, AMP-activated, beta 2 non-catalytic subunit
Introduction
PRKAB2 (Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2) is a protein coding gene. Among its related pathways are Gene Expression and mTOR Pathway. Gene Ontology annotations related to this gene include identical protein binding and AMP-activated protein kinase activity.
Entrez Gene ID
5565
UniProt ID
O43741
Alternative Names
AMPK Subunit Beta-2; 5-AMP-Activated Protein Kinase, Beta-2 Subunit
Function
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
Biological Process
Cellular response to nutrient levelsManual Assertion Based On ExperimentIDA:ComplexPortal
Fatty acid biosynthetic processIEA:UniProtKB-KW
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Regulation of catalytic activityIEA:InterPro
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
cytoplasm
cytosol
nucleoplasm
nucleotide-activated protein kinase complex
nucleus
PTM
Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-PRKAB2 Recombinant Antibody (2G9)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare