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Rat Anti-PROC Recombinant Antibody (CBYC-P645) (CBMAB-P2963-YC)

Provided herein is a Rat monoclonal antibody against Mouse Protein C, Inactivator Of Coagulation Factors Va And VIIIa. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PROC antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYC-P645
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PROC
Introduction
PROC is a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII.
Entrez Gene ID
19123
UniProt ID
Q64695
Alternative Names
APC; PC; PROC1; THPH3; THPH4
Function
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265).
Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845).
Biological Process
Blood coagulationIEA:UniProtKB-KW
Negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of blood coagulationManual Assertion Based On ExperimentIDA:ComplexPortal
Negative regulation of coagulationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of inflammatory responseManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of establishment of endothelial barrierManual Assertion Based On ExperimentIMP:UniProtKB
Proteolysis1 PublicationIDA:ComplexPortal
Cellular Location
Secreted
Golgi apparatus
Endoplasmic reticulum
Involvement in disease
Thrombophilia due to protein C deficiency, autosomal dominant (THPH3):
A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. Individuals with decreased amounts of protein C are classically referred to as having type I protein C deficiency and those with normal amounts of a functionally defective protein as having type II deficiency.
Thrombophilia due to protein C deficiency, autosomal recessive (THPH4):
A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. It results in a thrombotic condition that can manifest as a severe neonatal disorder or as a milder disorder with late-onset thrombophilia. The severe form leads to neonatal death through massive neonatal venous thrombosis. Often associated with ecchymotic skin lesions which can turn necrotic called purpura fulminans, this disorder is very rare.
PTM
The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.
N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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