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PROC

The PROC gene encodes protein C (EC 3.4.21.69), a vitamin K-dependent plasma glycoprotein that is a key component of the anticoagulant system. Protein C is cleaved to its activated form, 'activated protein C' (APC) on endothelial cells by the thrombin-thrombomodulin complex (MIM 176930; MIM 188040) and then acts as a serine protease to degrade the activated forms of coagulation factors V (F5; MIM 612309) and VIII (F8; see MIM 306700). Protein S (PROS1; MIM 176880), also a vitamin K-dependent plasma protein, functions as a cofactor to activated protein C.[supplied by OMIM
Full Name
PROC
Function
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265).
Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845).
Biological Process
Blood coagulationIEA:UniProtKB-KW
Negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of blood coagulationManual Assertion Based On ExperimentIDA:ComplexPortal
Negative regulation of coagulationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of inflammatory responseManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of establishment of endothelial barrierManual Assertion Based On ExperimentIMP:UniProtKB
Proteolysis1 PublicationIDA:ComplexPortal
Cellular Location
Secreted
Golgi apparatus
Endoplasmic reticulum
Involvement in disease
Thrombophilia due to protein C deficiency, autosomal dominant (THPH3):
A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. Individuals with decreased amounts of protein C are classically referred to as having type I protein C deficiency and those with normal amounts of a functionally defective protein as having type II deficiency.
Thrombophilia due to protein C deficiency, autosomal recessive (THPH4):
A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. It results in a thrombotic condition that can manifest as a severe neonatal disorder or as a milder disorder with late-onset thrombophilia. The severe form leads to neonatal death through massive neonatal venous thrombosis. Often associated with ecchymotic skin lesions which can turn necrotic called purpura fulminans, this disorder is very rare.
PTM
The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.
N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide.

Anti-PROC antibodies

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Target: PROC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: PC 7
Application*: E
Target: PROC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1161
Application*: WB, IP
Target: PROC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1886
Application*: WB
Target: PROC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0198
Application*: WB
Target: PROC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYC-P646
Application*: E, WB
Target: PROC
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYC-P645
Application*: E, WB
Target: PROC
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYC-P643
Application*: E, I, WB
Target: PROC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6B2
Application*: WB, E, P, IC, IF
Target: PROC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3A10
Application*: E, IP, WB
Target: PROC
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1E6
Application*: E, WB
Target: PROC
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 10g216
Application*: E
Target: PROC
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-C2738
Application*: WB, E
Target: PROC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYC-A1028
Application*: E, R, WB, AP
Target: PROC
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYC-A1027
Application*: E, WB, I
Target: PROC
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYC-A1026
Application*: E, WB, AP
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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