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Mouse Anti-PRODH Recombinant Antibody (CBYC-P649) (CBMAB-P2978-YC)

Provided herein is a Mouse monoclonal antibody against Human Proline dehydrogenase 1. The antibody can be used for immunoassay techniques, such as IHC-P, ELISA, WB.
See all PRODH antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P649
Antibody Isotype
IgG2a, κ
Application
IHC-P, ELISA, WB

Basic Information

Immunogen
PRODH (NP_057419, 441-540 aa) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
proline dehydrogenase (oxidase) 1
Introduction
PRODH is a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22.
Entrez Gene ID
UniProt ID
Alternative Names
TP53I6; POX; PRODH1; PRODH2; HSPOX2; PIG6
Function
Converts proline to delta-1-pyrroline-5-carboxylate.
Biological Process
4-hydroxyproline catabolic processManual Assertion Based On ExperimentTAS:BHF-UCL
Intrinsic apoptotic signaling pathway in response to oxidative stress1 PublicationNAS:UniProtKB
Positive regulation of cell deathManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Proline catabolic processTAS:Reactome
Proline catabolic process to glutamateManual Assertion Based On ExperimentIBA:GO_Central
Proline metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Mitochondrion matrix
Involvement in disease
Hyperprolinemia 1 (HYRPRO1):
An inborn error of proline metabolism resulting in elevated levels of proline in the plasma and urine. The disorder is generally benign and most affected individuals are clinically asymptomatic. Some patients, however, have neurologic manifestations, including epilepsy and intellectual disability. Association with certain forms of schizophrenia have been reported.
Schizophrenia 4 (SCZD4):
A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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