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Rat Anti-PROS1 Recombinant Antibody (CBYC-P655) (CBMAB-P2997-YC)

Provided herein is a Rat monoclonal antibody against Mouse Protein S. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PROS1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYC-P655
Antibody Isotype
IgG2a
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein corresponding to aa1-669 from mouse Protein S, CHO-derived
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-669

Target

Full Name
protein S
Introduction
PROS1 is a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia.
Entrez Gene ID
19128
UniProt ID
Q08761
Alternative Names
PROS; PS21; PS22; PS23; PS24; PS25; PSA; THPH5; THPH6
Function
Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
Biological Process
Blood coagulationManual Assertion Based On ExperimentTAS:ProtInc
FibrinolysisIEA:UniProtKB-KW
Cellular Location
Secreted
Involvement in disease
Thrombophilia due to protein S deficiency, autosomal dominant (THPH5):
A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. Based on the plasma levels of total and free PROS1 as well as the serine protease-activated protein C cofactor activity, three types of THPH5 have been described: type I, characterized by reduced total and free PROS1 levels together with reduced anticoagulant activity; type III, in which only free PROS1 antigen and PROS1 activity levels are reduced; and the rare type II which is characterized by normal concentrations of both total and free PROS1 antigen, but low cofactor activity.
Thrombophilia due to protein S deficiency, autosomal recessive (THPH6):
A very rare and severe hematologic disorder resulting in thrombosis and secondary hemorrhage usually beginning in early infancy. Some affected individuals develop neonatal purpura fulminans, multifocal thrombosis, or intracranial hemorrhage.
PTM
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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