PROS1

This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. [provided by RefSeq]
Full Name
protein S
Function
Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
Biological Process
Blood coagulationManual Assertion Based On ExperimentTAS:ProtInc
FibrinolysisIEA:UniProtKB-KW
Cellular Location
Secreted
Involvement in disease
Thrombophilia due to protein S deficiency, autosomal dominant (THPH5):
A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. Based on the plasma levels of total and free PROS1 as well as the serine protease-activated protein C cofactor activity, three types of THPH5 have been described: type I, characterized by reduced total and free PROS1 levels together with reduced anticoagulant activity; type III, in which only free PROS1 antigen and PROS1 activity levels are reduced; and the rare type II which is characterized by normal concentrations of both total and free PROS1 antigen, but low cofactor activity.
Thrombophilia due to protein S deficiency, autosomal recessive (THPH6):
A very rare and severe hematologic disorder resulting in thrombosis and secondary hemorrhage usually beginning in early infancy. Some affected individuals develop neonatal purpura fulminans, multifocal thrombosis, or intracranial hemorrhage.
PTM
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
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Anti-PROS1 antibodies

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Recombinant Rat Anti-PROS1 Antibody (CBHb220) (CBMAB-Hb903-LY)

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Target: PROS1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBHb220
Application*: FC, WB
Datasheet SDS

Rat Anti-PROS1 Recombinant Antibody (PS7) (CBMAB-X0206-FY)

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Target: PROS1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: PS7
Application*: F, WB
Datasheet SDS

Mouse Anti-PROS1 Recombinant Antibody (CBYC-P656) (CBMAB-P2999-YC)

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Target: PROS1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-P656
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-PROS1 Recombinant Antibody (8D5) (CBMAB-P2998-YC)

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Target: PROS1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 8D5
Application*: E
Datasheet SDS

Rat Anti-PROS1 Recombinant Antibody (CBYC-P655) (CBMAB-P2997-YC)

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Target: PROS1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYC-P655
Application*: E, WB
Datasheet SDS

Mouse Anti-PROS1 Recombinant Antibody (CBYC-P654) (CBMAB-P2996-YC)

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Target: PROS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYC-P654
Application*: E, R, WB
Datasheet SDS

Mouse Anti-PROS1 Recombinant Antibody (3D7) (CBMAB-P2995-YC)

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Target: PROS1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3D7
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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