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Rabbit Anti-PRR5L Recombinant Antibody (D19A5) (CBMAB-P3042-YC)

Provided herein is a Rabbit monoclonal antibody against Human Proline Rich 5 Like. The antibody can be used for immunoassay techniques, such as WB.
See all PRR5L antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
D19A5
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Proline Rich 5 Like
Introduction
PRR5L (Proline Rich 5 Like) is a protein coding gene. Among its related pathways are PI3K/Akt Signaling and mTOR signalling. Gene Ontology annotations related to this gene include ubiquitin protein ligase binding. An important paralog of the gene is PRR5.
Entrez Gene ID
Human79899
Monkey716934
UniProt ID
HumanQ6MZQ0
MonkeyF7HMD9
Alternative Names
PROTOR2
Function
Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (PubMed:17461779).
Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986).
Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress (PubMed:21964062).
Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress (PubMed:21964062).
Biological Process
Cellular response to oxidative stressManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of signal transductionIEA:UniProtKB-KW
Phosphatidylinositol 3-kinase signalingIEA:Ensembl
Positive regulation of intracellular protein transportManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of mRNA catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of phosphatidylinositol 3-kinase signalingIEA:Ensembl
Positive regulation of protein phosphorylationIEA:Ensembl
Protein phosphorylationIEA:Ensembl
Regulation of fibroblast migrationManual Assertion Based On ExperimentIMP:UniProtKB
TORC2 signalingManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
TORC2 complex
PTM
Ubiquitinated. Ubiquitination by RFFL promotes proteasomal degradation of PRR5L thereby modifying the substrate-specific activity of the mTORC2 complex. Ubiquitination by RFFL is stimulated by LPA/lysophosphatidic acid.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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