Rabbit Anti-PRR5L Recombinant Antibody (D19A5) (CBMAB-P3042-YC)

Name: Rabbit Anti-PRR5L Recombinant Antibody (D19A5)
SKU: CBMAB-P3042-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

D19A5

Application

Specificity

Human, Monkey

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Proline Rich 5 Like

Introduction

PRR5L (Proline Rich 5 Like) is a protein coding gene. Among its related pathways are PI3K/Akt Signaling and mTOR signalling. Gene Ontology annotations related to this gene include ubiquitin protein ligase binding. An important paralog of the gene is PRR5.

Entrez Gene ID

Human	79899
Monkey	716934

UniProt ID

Human	Q6MZQ0
Monkey	F7HMD9

Alternative Names

PROTOR2

Function

Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (PubMed:17461779).
Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986).
Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress (PubMed:21964062).
Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress (PubMed:21964062).

Biological Process

Cellular response to oxidative stressManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of signal transductionIEA:UniProtKB-KW
Phosphatidylinositol 3-kinase signalingIEA:Ensembl
Positive regulation of intracellular protein transportManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of mRNA catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of phosphatidylinositol 3-kinase signalingIEA:Ensembl
Positive regulation of protein phosphorylationIEA:Ensembl
Protein phosphorylationIEA:Ensembl
Regulation of fibroblast migrationManual Assertion Based On ExperimentIMP:UniProtKB
TORC2 signalingManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

TORC2 complex

PTM

Ubiquitinated. Ubiquitination by RFFL promotes proteasomal degradation of PRR5L thereby modifying the substrate-specific activity of the mTORC2 complex. Ubiquitination by RFFL is stimulated by LPA/lysophosphatidic acid.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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