PRR5L

PRR5L (Proline Rich 5 Like) is a protein coding gene. Among its related pathways are PI3K/Akt Signaling and mTOR signalling. Gene Ontology annotations related to this gene include ubiquitin protein ligase binding. An important paralog of the gene is PRR5.

Full Name

Proline Rich 5 Like

Function

Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (PubMed:17461779).
Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986).
Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress (PubMed:21964062).
Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress (PubMed:21964062).

Biological Process

Cellular response to oxidative stressManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of signal transductionIEA:UniProtKB-KW
Phosphatidylinositol 3-kinase signalingIEA:Ensembl
Positive regulation of intracellular protein transportManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of mRNA catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of phosphatidylinositol 3-kinase signalingIEA:Ensembl
Positive regulation of protein phosphorylationIEA:Ensembl
Protein phosphorylationIEA:Ensembl
Regulation of fibroblast migrationManual Assertion Based On ExperimentIMP:UniProtKB
TORC2 signalingManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

TORC2 complex

PTM

Ubiquitinated. Ubiquitination by RFFL promotes proteasomal degradation of PRR5L thereby modifying the substrate-specific activity of the mTORC2 complex. Ubiquitination by RFFL is stimulated by LPA/lysophosphatidic acid.