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Mouse Anti-PRSS12 Recombinant Antibody (CBYC-P671) (CBMAB-P3058-YC)

Provided herein is a Mouse monoclonal antibody against Human Serine Protease 12. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PRSS12 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P671
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
PRSS12 (NP_003610.1, 541-640 aa) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protease, serine, 12 (neurotrypsin, motopsin)
Introduction
PRSS12 is a member of the trypsin family of serine proteases and contains a signal peptide, a proline-rich region, a Kringle domain, four scavenger receptor cysteine-rich domains, and a trypsin-like serine protease domain. The protein, sometimes referred to as neurotrypsin or motopsin, is secreted from neuronal cells and localizes to the synaptic cleft. Studies in mice show that this protein cleaves a protein, agrin, that is important for the formation and maintenance of exitatory synapses.
Entrez Gene ID
8492
UniProt ID
P56730
Alternative Names
BSSP3; MRT1; BSSP-3
Function
Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
Biological Process
ExocytosisISS:UniProtKB
Zymogen activationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Involvement in disease
Intellectual developmental disorder, autosomal recessive 1 (MRT1):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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