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Mouse Anti-TMPRSS15 Recombinant Antibody (3F8) (CBMAB-A7104-LY)

The product is antibody recognizes PRSS7. The antibody 3F8 immunoassay techniques such as: WB, ELISA.
See all TMPRSS15 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3F8
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
PRSS7 (NP_002763, 361 a.a. ~ 470 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Transmembrane Protease, Serine 15
Introduction
This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq]
Entrez Gene ID
5651
UniProt ID
P98073
Alternative Names
ENTK; MGC133046
Function
Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.
Biological Process
Proteolysis
Cellular Location
Membrane
Involvement in disease
Enterokinase deficiency (ENTKD):
Life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive.
Topology
Cytoplasmic: 2-18
Helical: 19-47
Extracellular: 48-1019
PTM
The chains are derived from a single precursor that is cleaved by a trypsin-like protease.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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