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Mouse Anti-PRTN3 Recombinant Antibody (1F11) (CBMAB-P3085-YC)

Provided herein is a Mouse monoclonal antibody against Human Proteinase 3. The antibody can be used for immunoassay techniques, such as ELISA.
See all PRTN3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F11
Antibody Isotype
IgG2a
Application
ELISA

Basic Information

Immunogen
Human proteinase PR3 purified leukocyte mass
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS with 0.1% sodium azide, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
proteinase 3
Introduction
PRTN3 (Proteinase 3) is a protein coding gene. Diseases associated with PRTN3 include Wegener Granulomatosis and Vasculitis. Among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and C-MYB transcription factor network. Gene Ontology annotations related to this gene include enzyme binding and serine-type peptidase activity.
Entrez Gene ID
5657
UniProt ID
P24158
Alternative Names
ACPA; AGP7; C-ANCA; CANCA; MBN; MBT; NP-4; NP4; P29; PR-3; PR3
Function
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246).
By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369).
May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279).
Biological Process
Antimicrobial humoral responseTAS:Reactome
Cell-cell junction maintenanceManual Assertion Based On ExperimentIMP:UniProtKB
Collagen catabolic processIEA:UniProtKB-KW
Mature conventional dendritic cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Membrane protein ectodomain proteolysisManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of phagocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Neutrophil extravasationManual Assertion Based On ExperimentIMP:UniProtKB
PhagocytosisManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of GTPase activityManual Assertion Based On ExperimentIMP:UniProtKB
ProteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasmic granule
Secreted
Cell membrane
Membrane raft
Localizes predominantly to azurophil granules (primary secretory granules) in neutrophils (PubMed:2033050, PubMed:3198760, PubMed:7897245, PubMed:18462208).
Secreted upon neutrophil stimulation by TNF-alpha, lipopolysaccharide (LPS), fMLP and CXCL8/IL8 or during neutrophil transmigration (PubMed:22266279, PubMed:28240246).
Following secretion tethered to the cell membrane by CD177 (PubMed:18462208, PubMed:22266279).
Involvement in disease
Is the major autoantigen in anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (Wegener's granulomatosis) (PubMed:2377228, PubMed:2679910). This complex, systemic disease is characterized by granulomatous inflammation with necrotizing lesions in the respiratory tract, glomerulonephritis, vasculitis, and anti-neutrophil cytoplasmatic autoantibodies detected in patient sera (PubMed:2377228, PubMed:2679910). PRTN3 causes emphysema when administered by tracheal insufflation to hamsters (PubMed:3198760).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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